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Toll-like receptor signaling in the lysosomal pathways

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Lysosomal cysteine peptidase cathepsin l protects against cardiac hypertrophy through blocking akt/gsk3β signaling
Abstract  The lysosomal cysteine peptidase cathepsin L (CTSL) is an important lysosomal proteinase involved in a variety of cellular functions including intracellular protein turnover, epidermal homeostasis, and hair development. Deficiency of CTSL in mice results in a progressive dilated cardiomyopathy. In the present study, we tested the hypothesis that
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Somalia: Surge In Wounded And Displaced As Violence Increases In Mogadishu
The recent escalation in fighting in one of Mogadishu’s most populated residential areas has resulted in a surge of wounded civilians and has once again displaced thousands of people. The international medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF) is treating some of the wounded and
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The mhc class ii-associated invariant chain interacts with the neonatal fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments.
Related Articles The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments. J Immunol. 2008 Aug 15;181(4):2572-85
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La. Gov. Jindal Signs Ban On Funding For Research Involving Somatic Cell Nuclear Transfer
Louisiana Gov. Bobby Jindal (R) recently signed into law a bill (HB 370) that prohibits the use of state or federal funds for research involving human somatic cell nuclear transfer, the More: continued here
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Substantial Role In Autism Played By Chromosomal Abnormalities
Genome-wide scans of families affected by autism spectrum disorder (ASD) have revealed new evidence that previously unknown chromosomal abnormalities have a substantial role in the prevalent developmental disorder, according to a report published online Jan. 17th in the American Journal of Human Genetics, a publication of Cell
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