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Cutting edge: developmental up-regulation of ifn-gamma-inducible lysosomal thiol reductase expression leads to reduced t cell sensitivity and less severe autoimmunity.
Cutting edge: developmental up-regulation of IFN-gamma-inducible lysosomal thiol reductase expression leads to reduced T Cell Sensitivity and less severe autoimmunity. J Immunol. 2009 Jan 15;182(2):746-50 Authors: Maric M, Barjaktarevic I, Bogunovic B, Stojakovic M, Maric C, Vukmanovic S Reactivity
Cutting edge: developmental up-regulation of ifn-gamma-inducible lysosomal thiol reductase expression leads to reduced t cell sensitivity and less severe autoimmunity....

Final FDA approval for generic version of antiretroviral Zerit capsules
Mylan Inc. has announced that Matrix Laboratories Limited, its India-based subsidiary in which it holds a 71.5% controlling interest, received final approval from the U.S. Food and Drug Administration (FDA) on December 29, for its Abbreviated New Drug Application (ANDA) for Stavudine Capsules USP, 15 mg, 20
Final FDA approval for generic version of antiretroviral Zerit capsules...

Enhancement of mucosal and cellular immune response in mice by vaccination with respiratory syncytial virus dna encapsulated with transfersome
Viral Immunology Dec 2008, Vol. 21, No. 4: 483-490. Respiratory syncytial virus (RSV) is one of the principal causes of bronchiolitis and pneumonia in young children, and currently there is no safe and effective vaccine. DNA vaccines encoding RSV surface glycoproteins are one option being examined. We
Enhancement of mucosal and cellular immune response in mice by vaccination with respiratory syncytial virus dna encapsulated with transfersome...

Insertion of a targeting peptide on capsid surface loops of human papillomavirus type-16 virus-like particles mediate elimination of anti-dsdna abs-producing b cells with high efficiency.
Page: 36DOI: 10.1097/CJI.0b013e31818dbb8fAuthors: Wang, Huiming *; Yang, Zhao +; Li, Fan ++; He, Yani *; Wang, Shuguang [S]; Yang, Di +; Wu, Yuzhang + (Source: Journal of Immunotherapy)
Insertion of a targeting peptide on capsid surface loops of human papillomavirus type-16 virus-like particles mediate elimination of anti-dsdna abs-producing b cells with high efficiency....

Toll-like receptor signaling in the lysosomal pathways

Toll-like receptor signaling in the lysosomal pathways...

Lysosomal cysteine peptidase cathepsin l protects against cardiac hypertrophy through blocking akt/gsk3β signaling
Abstract  The lysosomal cysteine peptidase cathepsin L (CTSL) is an important lysosomal proteinase involved in a variety of cellular functions including intracellular protein turnover, epidermal homeostasis, and hair development. Deficiency of CTSL in mice results in a progressive dilated cardiomyopathy. In the present study, we tested the hypothesis that
Lysosomal cysteine peptidase cathepsin l protects against cardiac hypertrophy through blocking akt/gsk3β signaling...

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