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Modulation of dendritic cell function by cowshed dust extract.
Authors: Gorelik L, Kauth M, Gehlhar K, Bufe A, Holst O, Peters M We have shown previously that inhalation of cowshed dust extract (CDE) resulted in decreased airway reactivity, eosinophilic inflammation and sensitization in a mouse model of allergic asthma. Our data suggested down-regulation of
Modulation of dendritic cell function by cowshed dust extract....

Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms.
Invited review: Deterioration of the immune system after trauma: signals and cellular mechanisms. Innate Immun. 2008 Dec;14(6):333-44 Authors: Flohé SB, Flohé S, Schade FU Multiple trauma leads to a deterioration of the immune system. On the one hand, hyperinflammation
Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms....

Hemoglobin and streptococcus suis cell wall act in synergy to potentiate the inflammatory response of monocyte-derived macrophages.
In conclusion, hemoglobin, which may be released in vivo by the action of S. suis suilysin on red blood cells, contributes to raising the levels of pro-inflammatory mediators by acting in synergy with S. suis cell-wall components. This phenomenon may contribute to the development and the severity of
Hemoglobin and streptococcus suis cell wall act in synergy to potentiate the inflammatory response of monocyte-derived macrophages....

Increased resistance to cd4cd25 regulatory t cell-mediated suppression in patients with type 1 diabetes.
In conclusion, this work demonstrates that defective regulation is a feature of T1D regardless of disease duration and that an impaired ability of responder T cells to be suppressed contributes to this defect. PMID: 19037920 [PubMed - in process] (Source: Clinical and Developmental Immunology)
Increased resistance to cd4cd25 regulatory t cell-mediated suppression in patients with type 1 diabetes....

Cyclosporine use in miscellaneous clinical settings other than organ transplantations: is there any evidence for target levels?
Conclusions: Extended use of cyclosporine in several autoimmune diseases is promising. However, no evidence-based target levels in miscellaneous indications. Studies are needed to demonstrate overall bene fi ts of CSA in relation to trough level and dynamic indicators (biomarkers) like expression of IL-2 and its receptor as targeted
Cyclosporine use in miscellaneous clinical settings other than organ transplantations: is there any evidence for target levels?...

Markedly increased intracellular lipid droplets and disruption of intercellular junctions in biopsied myocardium from a patient with arrhythmogenic right ventricular cardiomyopathy
Abstract Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by the progressive replacement of myocardial cells by fat and fibrous tissue. Here we describe the histopathological features of biopsied myocardium from a patient with ARVC. A large amount of adipose tissue was present in the biopsy specimen, and a group
Markedly increased intracellular lipid droplets and disruption of intercellular junctions in biopsied myocardium from a patient with arrhythmogenic right ventricular cardiomyopathy...

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