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[Original articles] Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors
Conclusion: Our data suggest a novel function for wild-type huntingtin as a co-factor of LXR. However, this activity is lost by mutant huntingtin that only interacts weakly with LXR. (Source: Journal of Medical Genetics)
[Original articles] Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors...

Structural elucidation of metabolites of ginkgolic acid in rat liver microsomes by ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry and hydrogen/deuterium exchange.
This study might be useful for the investigation of toxicological mechanism of ginkgolic acids. PMID: 19462408 [PubMed - in process] (Source: Rapid Communications in Mass Spectrometry : RCM)
Structural elucidation of metabolites of ginkgolic acid in rat liver microsomes by ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry and hydrogen/deuterium exchange....

Ontario Women Live Longer Than Men But Don't Prosper
While Ontario women live longer than men, a majority are more likely to suffer from disability and chronic conditions, according to a new women's health study. What's more, low-income women have more chronic conditions, greater disability and a shorter life expectancy than women in high-income groups.
Ontario Women Live Longer Than Men But Don't Prosper...

Sirolimus Use in Stable Liver Transplant Patients May Increase Mortality
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Passenger Lymphocyte Syndrome and Liver Transplantation
The authors reviewed the passenger lymphocyte syndrome (PLS) that has appeared after transplantation. The definition, mechanism, serological, clinical features, and treatment for PLS after solid organ transplantation, especially liver transplantation, are described. The PLS refers to the clinical phenomenon of alloimmune hemolysis resulting from the adoptive transfer of
Passenger Lymphocyte Syndrome and Liver Transplantation...

Seniors who use cardiac rehabilitation live longer, study finds
Coronary heart disease (CHD) is the leading cause of death worldwide and a major driver of medical and economic costs, especially among older adults. It has long been established that cardiac rehabilitation improves survival, at least in middle-aged, low- and moderate-risk white men. Now a large Brandeis University-led
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