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Surgery Beats Nonsurgical Treatment for Herniated Discs: Direct Comparison Shows Most Outcomes Better With Discectomy
For patients with low back pain and other symptoms caused by herniated discs, surgery provides better results than nonsurgical treatment, according to a study in the December 1 issue of Spine.
Surgery Beats Nonsurgical Treatment for Herniated Discs: Direct Comparison Shows Most Outcomes Better With Discectomy...

An fhl1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice
The response of cardiomyocytes to biomechanical stress can determine the pathophysiology of hypertrophic cardiac disease, and targeting the pathways regulating these responses is a therapeutic goal. However, little is known about how biomechanical stress is sensed by the cardiomyocyte sarcomere to transduce intracellular hypertrophic signals or how the
An fhl1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice...

A cardiopulmonary exercise testing score for predicting outcomes in patients with heart failure.
CONCLUSION: A multivariable score based on readily available CPX responses provides a simple and integrated method that powerfully predicts outcomes in patients with HF. PMID: 19033016 [PubMed - in process] (Source: American Heart Journal) MedWorm Sponsored Message: Find out how you can get your message across
A cardiopulmonary exercise testing score for predicting outcomes in patients with heart failure....

Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in danish hypertrophic cardiomyopathy patients and relatives
The American Heart Association (AHA) recommends family screening for hypertrophic cardiomyopathy (HCM). We assessed the outcome of family screening combining clinical evaluation and screening for sarcomere gene mutations in a cohort of 90 Danish HCM patients and their close relatives, in all 451 persons. Index patients were screened
Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in danish hypertrophic cardiomyopathy patients and relatives...

Original investigation: comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy
Conclusions  Our findings from a large population-based cohort of US seniors are compatible with an increased risk of all-cause mortality and congestive heart failure in patients initiating therapy with rosiglitazone compared with similar patients initiating therapy with pioglitazone. Limitations of this study include residual confounding due to its
Original investigation: comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy...

Predictors and outcomes of consistent bronchodilator response identified
A study published in the Journal of Allergy and Clinical Immunology reports an association between consistent positive bronchodilator response (BDR) and baseline FEV1, immunoglobulin (Ig)E levels and status of corticosteroid treatment, in children with mild-moderate asthma. (Source: MedWire News - Respiratory)
Predictors and outcomes of consistent bronchodilator response identified...

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