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Recent related articles ( signal inflation):

Cutting edge: selective blockade of light-lymphotoxin {beta} receptor signaling protects mice from experimental cerebral malaria caused by plasmodium berghei anka.
In this study we report a role for LIGHT-lymphotoxin beta Receptor (LTbetaR) signaling in the development of ECM and control of parasite growth. Specific blockade of LIGHT-LTbetaR, but not LIGHT-herpesvirus entry mediator interactions, abrogated the accumulation of parasites and the recruitment of pathogenic CD8(+) T cells and monocytes
Cutting edge: selective blockade of light-lymphotoxin {beta} receptor signaling protects mice from experimental cerebral malaria caused by plasmodium berghei anka....

Nervous about immunity: neuronal signals control innate immune system
Authors: Cheng-Yuan Kao, Ferdinand C O Los & Raffi V Aroian The molecular mechanisms by which the nervous system influences innate immunity to pathogens remain mysterious. Two new studies show that neuronal products modulate established innate immune signaling pathways operative in the Caenorhabditis elegans intestine. (Source: Nature Immunology) MedWorm Sponsored Message:
Nervous about immunity: neuronal signals control innate immune system...

[mechanisms of signal transduction] dusp6 (mkp3) null mice show enhanced erk1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility
The strength and duration of mitogen-activated protein kinase signaling is regulated through phosphorylation and dephosphorylation by dedicated dual-specificity kinases and phosphatases, respectively. Here we investigated the physiological role that extracellular signal-regulated kinases 1/2 (ERK1/2) dephosphorylation plays in vivo through targeted disruption of the gene encoding dual-specificity phosphatase 6
[mechanisms of signal transduction] dusp6 (mkp3) null mice show enhanced erk1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility...

[original articles] epigenetic dysregulation of the wnt signalling pathway in chronic lymphocytic leukaemia
Conclusion: Wnt signalling is constitutively activated in CLL B lymphocytes in association with methylation of multiple soluble Wnt antagonist genes. Methylation of these soluble Wnt antagonist genes, occasionally multiple genes, in primary CLL marrow samples suggests an important role in CLL pathogenesis. Moreover, this study underscored the importance of
[original articles] epigenetic dysregulation of the wnt signalling pathway in chronic lymphocytic leukaemia...

Epilepsy: A New Relationship Between Brain Derived Neurotrophic Factor And Inflammatory Signaling
In the October 14th edition of Science Signaling researchers at Boston University School of Medicine (BUSM), The Children’s Hospital of Philadelphia/University of Pennsylvania School of Medicine and The University of Colorado Denver School of Medicine have shown that the development of epi More: continued here
Epilepsy: A New Relationship Between Brain Derived Neurotrophic Factor And Inflammatory Signaling...

From expression to signaling: roles of trem-1 and trem-2 in innate immunity and bacterial infection.
Related Articles From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology. 2008 Nov 6;213(9-10):701-713 Authors: Sharif O, Knapp S
From expression to signaling: roles of trem-1 and trem-2 in innate immunity and bacterial infection....

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