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Recent related articles ( signal inflation pressures):

Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms.
Invited review: Deterioration of the immune system after trauma: signals and cellular mechanisms. Innate Immun. 2008 Dec;14(6):333-44 Authors: Flohé SB, Flohé S, Schade FU Multiple trauma leads to a deterioration of the immune system. On the one hand, hyperinflammation
Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms....

Cutting edge: selective blockade of light-lymphotoxin {beta} receptor signaling protects mice from experimental cerebral malaria caused by plasmodium berghei anka.
In this study we report a role for LIGHT-lymphotoxin beta Receptor (LTbetaR) signaling in the development of ECM and control of parasite growth. Specific blockade of LIGHT-LTbetaR, but not LIGHT-herpesvirus entry mediator interactions, abrogated the accumulation of parasites and the recruitment of pathogenic CD8(+) T cells and monocytes
Cutting edge: selective blockade of light-lymphotoxin {beta} receptor signaling protects mice from experimental cerebral malaria caused by plasmodium berghei anka....

Nervous about immunity: neuronal signals control innate immune system
Authors: Cheng-Yuan Kao, Ferdinand C O Los & Raffi V Aroian The molecular mechanisms by which the nervous system influences innate immunity to pathogens remain mysterious. Two new studies show that neuronal products modulate established innate immune signaling pathways operative in the Caenorhabditis elegans intestine. (Source: Nature Immunology) MedWorm Sponsored Message:
Nervous about immunity: neuronal signals control innate immune system...

Comparison between tissue doppler imaging and velocity-encoded magnetic resonance imaging for measurement of myocardial velocities, assessment of left ventricular dyssynchrony, and estimation of left ventricular filling pressures in patients with ischemic cardiomyopathy.
In conclusion, TDI and VE-MRI are highly concordant and can be used interchangeably for the assessment of left ventricular dyssynchrony and filling pressures. PMID: 18993157 [PubMed - in process] (Source: The American Journal of Cardiology)
Comparison between tissue doppler imaging and velocity-encoded magnetic resonance imaging for measurement of myocardial velocities, assessment of left ventricular dyssynchrony, and estimation of left ventricular filling pressures in patients with ischemic cardiomyopathy....

[mechanisms of signal transduction] dusp6 (mkp3) null mice show enhanced erk1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility
The strength and duration of mitogen-activated protein kinase signaling is regulated through phosphorylation and dephosphorylation by dedicated dual-specificity kinases and phosphatases, respectively. Here we investigated the physiological role that extracellular signal-regulated kinases 1/2 (ERK1/2) dephosphorylation plays in vivo through targeted disruption of the gene encoding dual-specificity phosphatase 6
[mechanisms of signal transduction] dusp6 (mkp3) null mice show enhanced erk1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility...

[original articles] epigenetic dysregulation of the wnt signalling pathway in chronic lymphocytic leukaemia
Conclusion: Wnt signalling is constitutively activated in CLL B lymphocytes in association with methylation of multiple soluble Wnt antagonist genes. Methylation of these soluble Wnt antagonist genes, occasionally multiple genes, in primary CLL marrow samples suggests an important role in CLL pathogenesis. Moreover, this study underscored the importance of
[original articles] epigenetic dysregulation of the wnt signalling pathway in chronic lymphocytic leukaemia...

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