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Recent related articles ( tm novel beta):

Cutting edge: fimh adhesin of type 1 fimbriae is a novel tlr4 ligand.
In this study we report that FimH induces potent innate responses in a MyD88-dependent fashion. The FimH-induced innate activity was restricted to cells expressing TLR4. In addition, FimH was able to bind directly to TLR4. More importantly, cells unresponsive to LPS were responsive to FimH and the presence
Cutting edge: fimh adhesin of type 1 fimbriae is a novel tlr4 ligand....

Ifn-beta production by tlr4-stimulated innate immune cells is negatively regulated by gsk3-beta.
In this study, we demonstrate glycogen synthase kinase 3-beta (GSK3-beta) plays a fundamental role in this process. Suppression of GSK3-beta activity by either pharmacological inhibition, small interfering RNA-mediated gene silencing, or ectopic expression of a kinase-dead GSK3-beta mutant enhanced IFN-beta production by TLR4-stimulated macrophages. Conversely, ectopic expression of
Ifn-beta production by tlr4-stimulated innate immune cells is negatively regulated by gsk3-beta....

Deletion of gsk-3{beta} in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation
We report that terminal cardiomyocyte differentiation was substantially blunted in Gsk3b–/– embryoid bodies. While GSK-3α–deficient mice were born without a cardiac phenotype, no live-born Gsk3b–/– pups were recovered. The Gsk3b–/– embryos had a double outlet RV, ventricular septal defects, and hypertrophic myopathy, with near obliteration of the ventricular
Deletion of gsk-3{beta} in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation...

Reversal of iron-induced dilated cardiomyopathy during therapy with deferasirox in beta-thalassemia
A 15-year-old male with [beta]-thalassemia major developed dilated cardiomyopathy secondary to iron-overload (Z-scores of left ventricle (LV) dimensions >3, ejection fraction (EF) 33%). Treatment with deferoxamine was unsuccessful, presumably due to poor compliance. After 15 months of using deferasirox (DFX), LV end-diastolic dimension normalized (Z-scores (Source: Pediatric Blood
Reversal of iron-induced dilated cardiomyopathy during therapy with deferasirox in beta-thalassemia...

A novel cd19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells.
Page: 871DOI: 10.1097/CJI.0b013e318186c8b4Authors: Kellner, Christian *; Bruenke, Joerg *; Stieglmaier, Julia *; Schwemmlein, Michael *; Schwenkert, Michael *; Singer, Heiko *; Mentz, Kristin *; Peipp, Matthias +; Lang, Peter ++; Oduncu, Fuat [S]; Stockmeyer, Bernhard [//]; Fey, Georg H. * (Source: Journal of Immunotherapy) MedWorm Sponsored Message: MD Consult
A novel cd19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells....

Trius Therapeutics awarded $28 million to develop novel drugs targeting bacterial DNA Gyrase and Topoisomerase IV
Trius Therapeutics, Inc., today announced the award of a $28 million contract from the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health, for the development of novel antibiotics directed against multiple Gram-negative bacterial pathogens.
Trius Therapeutics awarded $28 million to develop novel drugs targeting bacterial DNA Gyrase and Topoisomerase IV...

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